Nitric Oxide, is an exhaled biomarker of airway / alveoli inflammation.

It is a simple non interventional tool, that allows us to collect selectively exhaled Nitrogen Oxide from the airway or alveoli, depending on the expiratory flow settings applied. Setting for a low expiratory flow (50ml/sec), the method determines the presence and severity of airway inflammation typically associated with asthma, and evaluates the response to corticosteroid treatment.

Therefore, FeNO helps identify the patient who will, or will not benefit of inhaled corticosteroids, while it also facilitates the monitoring of its progress. The easy, non-invasive procedure makes this method ideal for the diagnosis and monitoring of childhood asthma. Using higher expiratory flow settings(multiflow FeNO), allows us to measure the Alveolar Exhaled NO,

a marker of alveolar inflammation (alveolitis), applicable in the diagnosis and monitoring of interstitial lung diseases.

Conditions associated with increased FeNO values: Asthma, atopy, non-asthmatic eosinophilic bronchitis, COPD exacerbation, upper respiratory viral infections, bronchiectasis.

Conditions that lower FeNO: smoking, cystic fibrosis, pulmonary hypertension, ciliary dyskinesia, hypothermia, bronchopulmonary dysplasia.

FeNO values are influenced by various factors such as exercise, air pollution, chemicals, food preservatives, coffee, soft drinks, medications and lung diseases (e.g., sarcoidosis).